DNA replication initiation in Saccharomyces cerevisiae

Origin specification through bidirectional fork formation. Eleven steps on the main line, with legends, regulation, two accounts of the second load and seven perturbations on a second chart. Shape carries function: where two proteins bind, the outline of one is cut to receive the other. Content follows Parker, Botchan and Berger (2017), the work it cites, and later structural and in vivo work named in the captions. The third chart is different in kind: it draws the firing models for CST that this dissertation proposes, set on the steps they would act at, and none of them is an established mechanism.